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濂ュ笇鏇垮凹 |
鍙ｆ湇甯搁噴鍓傚瀷 |
闄愭棦寰€鍥犺〃鐨敓闀垮洜瀛愬彈浣擄紙EGFR锛夐叒姘ㄩ吀婵€閰舵姂鍒跺墏锛圏/span>TKI锛夋不鐤楁椂鎴栨不鐤楀悗鍑虹幇鐤剧梾杩涘睍锛屽苟涓旂粡妫€楠岀‘璁ゅ瓨鍦?/span>EGFR T790M绐佸彉闃虫€х殑灞€閮ㄦ櫄鏈熸垨杞Щ鎬ч潪灏忕粏鑳炶偤鐧屾垚浜烘偅鑰呫€侟/span> |
|
13 |
瀹夌綏鏇垮凹 |
鍙ｆ湇甯搁噴鍓傚瀷 |
闄愭棦寰€鑷冲皯鎺ュ彈杩嘃/span>2绉嶇郴缁熷寲鐤楀悗鍑虹幇杩涘睍鎴栧鍙戠殑灞€閮ㄦ櫄鏈熸垨杞Щ鎬ч潪灏忕粏鑳炶偤鐧屾偅鑰呫€侟/span> |
|
14 |
鍏嬪攽鏇垮凹 |
鍙ｆ湇甯搁噴鍓傚瀷 |
闄愰棿鍙樻€ф穻宸寸槫婵€閰讹紙ALK锛夐槼鎬х殑灞€閮ㄦ櫄鏈熸垨杞Щ鎬ч潪灏忕粏鑳炶偤鐧屾偅鑰呮垨ROS1闃虫€х殑鏅氭湡闈炲皬缁嗚優鑲虹檶鎮ｈ€呫€侟/span> |
|
15 |
濉炵憺鏇垮凹 |
鍙ｆ湇甯搁噴鍓傚瀷 |
鎺ュ彈杩囧厠鍞戞浛灏兼不鐤楀悗杩涘睍鐨勬垨鑰呭鍏嬪攽鏇垮凹涓嶈€愬彈鐨勯棿鍙樻€ф穻宸寸槫婵€閰讹紙ALK锛夐槼鎬у眬閮ㄦ櫄鏈熸垨杞Щ鎬ч潪灏忕粏鑳炶偤鐧屾偅鑰呫€侟/span> |
|
16 |
闃挎様鏇垮凹 |
鍙ｆ湇甯搁噴鍓傚瀷 |
闄愭棦寰€鎺ュ彈杩囦竴绉嶉叒姘ㄩ吀婵€閰舵姂鍒跺墏鎴栫粏鑳炲洜瀛愭不鐤楀け璐ョ殑杩涘睍鏈熻偩缁嗚優鐧孅/span>(RCC)鐨勬垚浜烘偅鑰呫€侟/span> |
|
17 |
鐟炴垐闈炲凹 |
鍙ｆ湇甯搁噴鍓傚瀷 |
1.鑲濈粏鑳炵檶浜岀嚎娌荤枟锛汓/span>2.杞Щ鎬х粨鐩磋偁鐧屼笁绾挎不鐤楋紱3.鑳冭偁閬撻棿璐ㄧ槫涓夌嚎娌荤枟銆侟/span> |
|
18 |
鑸掑凹鏇垮凹 |
鍙ｆ湇甯搁噴鍓傚瀷 |
1.涓嶈兘鎵嬫湳鐨勬櫄鏈熻偩缁嗚優鐧岋紙RCC)锛汓/span>2.鐢茬：閰镐紛椹浛灏兼不鐤楀け璐ユ垨涓嶈兘鑰愬彈鐨勮儍鑲犻棿璐ㄧ槫锛圏/span>GIST)锛汓/span>3.涓嶅彲鍒囬櫎鐨勶紝杞Щ鎬ч珮鍒嗗寲杩涘睍鏈熻儼鑵虹缁忓唴鍒嗘硨鐦わ紙pNET锛夋垚浜烘偅鑰呫€侟/span> |
|
19 |
浼婂竷鏇垮凹 |
鍙ｆ湇甯搁噴鍓傚瀷 |
1.鏃㈠線鑷冲皯鎺ュ彈杩囦竴绉嶆不鐤楃殑濂楃粏鑳炴穻宸寸槫锛圏/span>MCL锛夋偅鑰呯殑娌荤枟锛汓/span>2.鎱㈡€ф穻宸寸粏鑳炵櫧琛€鐥匋/span>/灏忔穻宸寸粏鑳炴穻宸寸槫锛圏/span>CLL/SLL锛夋偅鑰呯殑娌荤枟銆侟/span> |
|
20 |
缁磋帿闈炲凹 |
鍙ｆ湇甯搁噴鍓傚瀷 |
娌荤枟缁廃/span>CFDA鎵瑰噯鐨勬娴嬫柟娉曠‘瀹氱殑BRAF V600绐佸彉闃虫€х殑涓嶅彲鍒囬櫎鎴栬浆绉绘€ч粦鑹茬礌鐦ゃ€侟/span> |
|
21 |
浼婃矙浣愮背 |
鍙ｆ湇甯搁噴鍓傚瀷 |
1.姣廃/span>2涓枟绋嬮渶鎻愪緵娌荤枟鏈夋晥鐨勮瘉鎹悗鏂瑰彲缁х画鏀粯锛汓/span>2.鐢变笁绾у尰闄㈣娑蹭笓绉戞垨琛€娑蹭笓绉戝尰闄㈠尰甯堝鏂癸紱3.涓庢潵閭ｅ害鑳鸿仈鍚堜娇鐢ㄦ椂锛屽彧鏀粯浼婃矙浣愮背鎴栨潵閭ｅ害鑳轰腑鐨勪竴绉嶃€侟/span> |
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闄勪欢2 鏂板鍩烘湰鍖荤枟淇濋櫓闂ㄨ瘖澶х梾鐢ㄨ嵂鐩綍
搴忓彿 |
鑽搧鍚嶇О |
鍓傚瀷 |
澶囨敞 |
闂ㄨ瘖澶х梾鏍囧織 |
1 |
濂ユ洸鑲键/span> |
寰悆娉ㄥ皠鍓侟/span> |
闄愯儍鑲犺儼鍐呭垎娉岃偪鐦ゃ€佽偄绔偉澶х棁锛屾寜璇存槑涔︾敤鑽€侟/span> |
鎭舵€ц偪鐦｜/span> |
2 |
闃挎墡鑳炶嫹 |
娉ㄥ皠鍓侟/span> |
鎴愬勾鎮ｈ€呬腑1.鍥介檯棰勫悗璇勫垎绯荤粺锛圏/span>IPSS锛変腑鐨勪腑鍗包/span>-2鍙婇珮鍗遍楂撳鐢熷紓甯哥患鍚堝緛锛圏/span>MDS)锛汓/span>2.鎱㈡€х矑-鍗曟牳缁嗚優鐧借鐥咃紙CMML)锛汓/span>3.鎸夌収涓栫晫鍗敓缁勭粐锛圏/span>WHO锛夊垎绫荤殑鎬ユ€ч珦绯荤櫧琛€鐥咃紙AML锛夈€侀楂撳師濮嬬粏鑳炰负20-30%浼村绯诲彂鑲插紓甯哥殑娌荤枟銆侟/span> |
鎭舵€ц偪鐦｜/span> |
3 |
鍩归棬鍐叾 |
娉ㄥ皠鍓侟/span> |
鍎跨鎬ユ€ф穻宸寸粏鑳炵櫧琛€鐥呮偅鑰呯殑涓€绾挎不鐤椼€侟/span> |
鎭舵€ц偪鐦｜/span> |
4 |
纭煿闈炴牸鍙镐涵 |
娉ㄥ皠鍓侟/span> |
闄愬墠娆″寲鐤楁浘鍙戠敓閲嶅害涓€х矑缁嗚優鍑忓皯鍚堝苟鍙戠儹鐨勬偅鑰呫€侟/span> |
鎭舵€ц偪鐦｜/span> |
鎵竴鎵湪鎵嬫満鎵撳紑褰撳墠椤袋/p>
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